The efficacy of spirulina: reduce the side effects of cancer radiotherapy and chemotherapy; improve immune function; lower blood lipids. Adjuvant therapy for primary cancer; hyperlipidemia; iron deficiency anemia; diabetes; malnutrition; physical weakness after illness;


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1. Anti-radiation damage


Oral administration of spirulina to mice before and after radiation exposure can increase the survival rate of mice. The effective dose is 3.75-15 mg (156-625 mg/kg body weight, 2-5 times of taking). Spirulina was administered 3 times, and on the 9th day after 7.5 Gy irradiation, observation of sensitive organs of irradiated animals showed that spirulina could increase the thymus weight and bone marrow DNA content of irradiated mice compared with the control group, indicating that Spirulina It has protective effects on immune organs and hematopoietic tissues, which may be one of the mechanisms of spirulina's resistance to radiation damage.


2, antibacterial effect


Spirulina platensis has a bacteriostatic effect on Gram-positive bacteria. The ethanol extract of Spirulina platensis, which contains lipids and triterpenoids, has the strongest antibacterial activity, and the sterol-containing extract also has antibacterial effect, but the effect is better. weak. Spirulina platensis has no inhibitory effect on Gram-negative bacteria.


3, anti-cancer effect


Spirulina inhibited the formation of large intestine degeneration crypts in NIH mice and standard deviation rats induced by short-term injection and long-term multiple injections of 1,2-dimethylhydrazine. Spirulina polysaccharide has a significant inhibition rate on ascites-type hepatocarcinoma cells in the treatment group, 54.0% in the treatment group and 91.4% in the control group. The inhibition of DNA, RNA and protein in cancer cells is enhanced with the prolongation of the action time.


4, photosensitization


The cultured mouse myeloma cells were treated with 0.25 mg/ml phycocyanin (phycocyanin), and then irradiated with 514 nm laser at 300 J/cm2, and the cancer cell survival rate was only 15%; instead, laser irradiation or The phycocyanin treatment, cell viability was 69% and 71%. Human colorectal cancer cell line HR8348 was cultured with 100 μg, 50 μg, 25 μg of phycocyanin from Spirulina platensis, irradiated with 12 J/cm 2 of copper laser with 630 nm light wave, and the survival rate of cultured cancer cells was determined by MTT method. 22.2%, 37.6% and 89.7%, showing good dose effects. After sarcocyst S180 mice were given 2 mg or 20 mg orally, the effective rate was 50% and 53% after 15 days of irradiation with copper laser, which was significantly different from the control group. In vitro and in vivo tests have confirmed that phycocyanin does have photosensitivity and is non-toxic and side-effect, making it an ideal photosensitizer.


5. The role of the immune system


Spirulina polysaccharide can increase the serum hemolysin in mice by 39.5%-98.0%, the phagocytic rate of peritoneal macrophages by 32.5%-51.5%, the phagocytic index by 0.9-1.8 times, and the number of T lymphocytes by 46.8%-87.7%. The spleen white pulp lymphocytes are densely arranged, the macrophages in the red pulp are significantly increased, and the acid α-naphthyl acetate esterase (ANAE) positive lymphocytes are increased by 7.3%-12.8%.






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6, lower cholesterol


Thirty males with high cholesterol and mild hyperlipidemia were divided into two groups. Group A received 4.2 g of spirulina daily for 8 weeks, and serum total cholesterol decreased from 6.3 mmol/L (244 mg/dl) within 4 weeks. To 6.1 mmol/L (233 mg/dl), the drop was 4.5%. Group B stopped for 4 weeks, and the total serum cholesterol decreased, and then returned to the original level. Low-density lipoprotein cholesterol was significantly reduced by 6.1% in 4 weeks, and people with high cholesterol levels had a greater decrease in serum cholesterol.


7. Improve the bioavailability of iron and regulate anemia


Pure Wistar rats were selected, the iron deficiency anemia model was replicated by low-iron diet, and the recovery test was carried out with spirulina. The ferrous sulfate was used as the positive control group, the low iron diet was used as the negative control group, and the spirulina content was small. The score was divided into 3 experimental groups, and the contents were 1%, 8%, and 15%, respectively. RESULTS: The body weight of the experimental group 2 and the experimental group 3 was higher than that of the positive control group. It is suggested that simple iron deficiency can affect the growth of rats, resulting in slow growth of rat weight, while spirulina has the effect of accelerating the weight gain of rats, and it has significant effect on the recovery of iron deficiency anemia in rats. Another trial conducted in Japan was to limit the diet of eight young women over a longer period of time, showing sub-permanent anemia -- hemoglobin was below normal, and then eating 4 g of spirulina after each meal for 80 days. Hemoglobin increased by 21%, from 109g / L to 132g / L, no longer anemia.


8. Help build a healthy Lactobacillus group


In mice fed spirulina, the lactobacillus content in the body was increased by three times compared with the control group. Adding 5% spirulina to the diet of the mice for 100 days resulted in a 13% increase in the weight of the cecum, a 327% increase in lactobacilli, and a 43% increase in the cecal vitamin B1. Spirulina did not provide this extra vitamin B1, but improved the absorption of the entire vitamin B1. It shows that the consumption of spirulina increases the number of lactobacilli in the body and increases the efficiency of the body to absorb vitamin B1 and other vitamins from the diet.


9, the protection of the stomach


Spirulina platensis 250-500mg/kg can significantly protect the experimental rat gastric ulcer model of indomethacin (indomethacin) and absolute ethanol; it can reduce the occurrence of ulceration model of pylorus ligation rat The rate and the number of ulcers have a certain inhibitory effect on the secretion of gastric juice; it can accelerate the healing of gastric ulcer in chronic acetic acid rats.


10. Reduce the toxicity of mercury and drugs to the kidneys


Injecting the prepared high-concentration organic mercury drugs into mice showed that the blood urea nitrogen (BUN) of nephrotoxicity increased by 310%, serum creatine increased by 198%, and BUN decreased by 20% after adding 30% of spirulina to the diet. Serum creatine was reduced by 157%, and 2 cases were reduced to the initial level. Similar symptoms can be observed after giving ordinary drugs to rats, such as analgesics, antibiotics, anticancer drugs, etc